Sodium Carbonate → HCID 73796032, compound

Participants

Reaction Steps

A mixture of hydroxylamine hydrochloride (0.09 mole) in methanol (230 ml), sodium carbonate (4.8 g, 0.045 mole) in 50 ml of water and 2-trifluoromethylthio-2-methylpropionaldehyde (14.85 g, 0.086 mole) from Step 1 was stirred at room temperature overnight. The reaction mixture was poured into water, the oxime was extracted into diethyl ether, the combined ether extracts were washed with water and then dried. The drying agent was removed by filtration and the filtrate was distilled to provide 2-trifluoromethylthio-2-methylpropionaldehyde oxime, b.p. 80°C/18 mm. The structure of this product was confirmed by elemental and spectroscopic analyses.

Provenance & Evidence