Sodium Carbonate → HCID 73796032, compound

HRID 1578558Notes

Reaction equation

HRID 1578558 reaction equation
Cl.[NH2:2][OH:3].C(=O)([O-])[O-].[Na+].[Na+].[F:10][C:11]([F:19])([F:18])[S:12][C:13]([CH3:17])([CH3:16])[CH:14]=O>CO.O>[F:10][C:11]([F:19])([F:18])[S:12][C:13]([CH3:17])([CH3:16])[CH:14]=[N:2][OH:3]

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 21559438HCID 21559438, compound

Product 1

HCID 73796032HCID 73796032, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

A mixture of hydroxylamine hydrochloride (0.09 mole) in methanol (230 ml), sodium carbonate (4.8 g, 0.045 mole) in 50 ml of water and 2-trifluoromethylthio-2-methylpropionaldehyde (14.85 g, 0.086 mole) from Step 1 was stirred at room temperature overnight. The reaction mixture was poured into water, the oxime was extracted into diethyl ether, the combined ether extracts were washed with water and then dried. The drying agent was removed by filtration and the filtrate was distilled to provide 2-trifluoromethylthio-2-methylpropionaldehyde oxime, b.p. 80°C/18 mm. The structure of this product was confirmed by elemental and spectroscopic analyses.

Workup

  1. extractionthe oxime was extracted into diethyl ether
  2. washthe combined ether extracts were washed with water
  3. customdried
  4. customThe drying agent was removed by filtration
  5. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-7b20f25695af4e8c8045e423a8ed33ba
Source dataset
uspto-grants-1976_02
Patent number
US03937738

Reaction notes

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