反应详情

N-Methoxychloroacetamide (12.3 grams; 0.1 mole), benzene (60 ml) and dibutyltin dilaurate (1 drop) are charged into a glass reaction flask equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Methyl-4-methylthiophenylisocyanate (21.5 grams; 0.12 mole) dissolved in benzene (30 ml) is incrementally added to the reaction mixture, with stirring, at room temperature. After the addition is completed the reaction mixture is heated at reflux for a period of about 2 hours. After this time the reaction mixture is distilled to remove benzene and unreacted starting material thereby yielding the desired product 1-chloro-2-[N-(2-methyl-4-methylthiophenyl)carbamoyloxy]-2-methoxyiminoethane.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. additionis incrementally added to the reaction mixture
4. additionAfter the addition
5. temperatureis heated
6. temperatureat reflux for a period of about 2 hours
7. distillationAfter this time the reaction mixture is distilled
8. customto remove benzene