3-Aminopyridine → HCID 3089072, compound

HRID 1578714Notes

Reaction equation

HRID 1578714 reaction equation
[CH2:1]([N:10]=[C:11]=[O:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]=[C:8]=[O:9].[NH2:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1>C1(C)C=CC=CC=1>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([NH:13][C:8](=[O:9])[NH:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:1][NH:10][C:11]([NH:13][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:12])[CH:15]=1

Participants

4

Reactant 2

HCID 100093-AminopyridineHCID 13192Hexamethylene diisocyanate

Product 1

HCID 3089072HCID 3089072, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of hexamethylene di-isocyanate (1.68g.) in toluene (10ml.) was added to a solution of 3-aminopyridine (1.88g.) in toluene (18ml.) and the mixture was heated on a steam-bath for 10 minutes. The mixture was cooled, and the product was filtered off, washed with toluene and dried, to give 1,6-bis[3-(pyrid-3-yl)ureido]hexane, m.p. 197°-199°C., the starting material for compound 67.

Workup

  1. temperaturethe mixture was heated on a steam-bath for 10 minutes
  2. temperatureThe mixture was cooled
  3. filtrationthe product was filtered off
  4. washwashed with toluene
  5. customdried

Sources & evidence

ORD record
ord-840d26256b4d4d41ba2c88fffd9d1ffb
Source dataset
uspto-grants-1976_02
Patent number
US03939169

Reaction notes

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