HCID 24192289, compound → HCID 135783944, compound

HRID 1578731Notes

Reaction equation

HRID 1578731 reaction equation
Cl[C:2]1[C:10]2[NH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[N:7][C:6]=2[C:5]([N+:15]([O-:17])=[O:16])=[CH:4][C:3]=1[C:18]([F:21])([F:20])[F:19].[C:22]([O:30][CH2:31][CH3:32])(=[O:29])[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25].[K]>>[C:22]([CH:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:2]1[C:10]2[NH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[N:7][C:6]=2[C:5]([N+:15]([O-:17])=[O:16])=[CH:4][C:3]=1[C:18]([F:21])([F:20])[F:19])([O:30][CH2:31][CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 24192289HCID 24192289, compoundHCID 1355549354-Chloro-7-nitro-2,5-bis(trifluoromethyl)benzimidazole

Product 1

HCID 135783944HCID 135783944, compound

Procedure

4-Chloro-7-nitro-2,5-bis(trifluoromethyl)benzimidazole is reacted with potassium diethyl malonate to obtain 4-(bis(carboethoxy)methyl)-7-nitro-2,5-bis(trifluoromethyl)-benzimidazole; this intermediate is deesterified and decarboxylated to yield 4-methyl-7-nitro-2,5-bis(trifluoromethyl)-benzimidazole, m.w., 313.2. In like procedures, the following are prepared:

Sources & evidence

ORD record
ord-ffce85cfb56c49e383455980e26336ef
Source dataset
uspto-grants-1976_02
Patent number
US03939166

Reaction notes

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