Thiazol-4-amine → 2,2,2-trifluoro-N-(thiazol-4-yl)acetamide

HRID 1578743Notes

Reaction equation

HRID 1578743 reaction equation
NC1N=CSC=1.Br[C:8]1[S:9][CH:10]=[C:11]([NH:13][C:14](=[O:19])[C:15]([F:18])([F:17])[F:16])[N:12]=1>>[F:18][C:15]([F:16])([F:17])[C:14]([NH:13][C:11]1[N:12]=[CH:8][S:9][CH:10]=1)=[O:19]

Participants

3

Reactant 2

HCID 14009640Thiazol-4-amineHCID 20377171N-(2-bromothiazol-4-yl)-2,2,2-trifluoroacetamide

Product 1

HCID 214496592,2,2-trifluoro-N-(thiazol-4-yl)acetamide

Procedure

The method of preparing 4-aminothiazole comprising reacting 2-bromo-4-trifluoroacetamidothiazole under low pressure catalytic hydrogenation conditions in the presence of a noble metal catalyst to give 4-trifluoroacetamidothiazole then reacting said 4-trifluoroacetamidothiazole with sodium or potassium hydroxide in an aqueous medium at from about 30°-35°C. for about 4-8 hours.

Sources & evidence

ORD record
ord-1b97e08cca10462d88ec4b3e0cb5471c
Source dataset
uspto-grants-1976_02
Patent number
US03939172

Reaction notes

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