Thiazol-4-amine → 2,2,2-trifluoro-N-(thiazol-4-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	Thiazol-4-amine	HCID 14009640	—
Reactant	N-(2-bromothiazol-4-yl)-2,2,2-trifluoroacetamide	HCID 20377171	—
Product	2,2,2-trifluoro-N-(thiazol-4-yl)acetamide	HCID 21449659	—

Reaction Steps

The method of preparing 4-aminothiazole comprising reacting 2-bromo-4-trifluoroacetamidothiazole under low pressure catalytic hydrogenation conditions in the presence of a noble metal catalyst to give 4-trifluoroacetamidothiazole then reacting said 4-trifluoroacetamidothiazole with sodium or potassium hydroxide in an aqueous medium at from about 30°-35°C. for about 4-8 hours.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US03939172
Source dataset	uspto-grants-1976_02
ORD ID	ord-1b97e08cca10462d88ec4b3e0cb5471c
Source note	uspto-grants-1976_02