反应详情

A solution of 11.02 g of 1-acetyl-cyclopent-1-ene in 50 ml of methanol is cooled to -10°C and mixed with 28.8 ml of perhydrol within 5 minutes. In the course of 1 hour, while stirring and cooling, 8.25 ml of 6N-sodium hydroxide solution are added, the whole is stirred for 1/2 hour at room temperature, diluted with 125 ml of water and extracted with pentane. The pentane solution is washed neutral with sodium chloride solution and the pentane is distilled off through a Vigreux column. The residue is distilled under 10 mm Hg pressure, to yield 1-acetyl-1,2-epoxy-cyclopentane passing over at 62° - 63°C.

1. temperaturecooling
2. stirringthe whole is stirred for 1/2 hour at room temperature
3. extractionextracted with pentane
4. washThe pentane solution is washed neutral with sodium chloride solution
5. distillationthe pentane is distilled off through a Vigreux column
6. distillationThe residue is distilled under 10 mm Hg pressure