反应详情

Acetic anhydride (2.67 g.) in dichloroethane (10 ml.) was added deopwise to a stirred, cooled (0°) suspension of aluminum chloride (6.95 g.) in dichloroethane (20 ml.). Cooling and stirring were continued during the dropwise addition of a solution of 2-ethylfluorene (4.61 g.) in dichloroethane (50 ml.). The mixture was stirred for one hour at room temperature and then decomposed by the dropwise addition of 2N-hydrochloric acid (40 ml.) to the cooled solution. The organic layer was separated, washed with water and with aqueous sodium bicarbonate, dried over anhydrous sodium sulphate, filtered, and evaporated under reduced pressure. The residue was recrystallised from light petroleum (ca 250 ml., b.p. 60°-80°) to give 2-acetyl-7-ethylfluorene m.p. 120°-122°.

1. temperaturecooled
2. temperatureCooling
3. stirringThe mixture was stirred for one hour at room temperature
4. customThe organic layer was separated
5. washwashed with water and with aqueous sodium bicarbonate
6. dry with materialdried over anhydrous sodium sulphate
7. filtrationfiltered
8. customevaporated under reduced pressure
9. customThe residue was recrystallised from light petroleum (ca 250 ml., b.p. 60°-80°)