Sodium Carbonate → HCID 53696539, compound

HRID 1578942Notes

Reaction equation

HRID 1578942 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][S:6][C:7]1[N:12]=[C:11](Cl)[CH:10]=[C:9]([Cl:14])[N:8]=1)[CH3:2].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][S:6][C:7]1[N:8]=[C:9]([Cl:14])[CH:10]=[C:11]([N:26]2[CH2:25][CH2:24][N:23]([C:20]3[CH:19]=[CH:18][C:17]([Cl:16])=[CH:22][CH:21]=3)[CH2:28][CH2:27]2)[N:12]=1)[CH3:2]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 974781-(4-Chlorophenyl)piperazineHCID 4133103Acetic acid, [(4,6-dichloro-2-pyrimidinyl)thio]-, ethyl ester

Product 1

HCID 53696539HCID 53696539, compoundYield 62.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5.3 g of (4,6-dichloro-2-pyrimidinylthio) acetic acid ethyl ester, 3.9 g of N-(p-chlorophenyl)piperazine and 2.1 g of sodium carbonate in 120 ml. of ethanol was warmed on a steam bath for 10 minutes. The reaction mixture was filtered and the filtrate was diluted with water in order to cause precipitation. The precipitate was recrystallized from ethanol to afford 5.3 g of product, mp. 117°-120°C.

Workup

  1. filtrationThe reaction mixture was filtered
  2. additionthe filtrate was diluted with water in order
  3. customprecipitation
  4. customThe precipitate was recrystallized from ethanol

Sources & evidence

ORD record
ord-d057d328734d4c48b724d52ed76fb771
Source dataset
uspto-grants-1976_02
Patent number
US03940394

Reaction notes

Loading…