Ammonium Hydroxide → 2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetamide

HRID 1578944Notes

Reaction equation

HRID 1578944 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=2[CH3:16])[N:5]=[C:4]([S:17][CH2:18][C:19]([O:21]CC)=O)[N:3]=1.[OH-].[NH4+:25]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=2[CH3:16])[N:5]=[C:4]([S:17][CH2:18][C:19]([NH2:25])=[O:21])[N:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 9798569HCID 9798569, compound

Product 1

HCID 215573412-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.0 g of [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid, ethyl ester was added to 40 ml of concentrated ammonium hydroxide. Ethanol (40 ml) was then added and the reaction mixture was boiled to give a clear solution. This solution then stood at room temperature for three days. The precipitate thus formed was collected and recrystallized from ethanol giving 3.0 g of product, mp. 188°-191°C.

Workup

  1. customto give a clear solution
  2. customThe precipitate thus formed
  3. customwas collected
  4. customrecrystallized from ethanol giving 3.0 g of product, mp. 188°-191°C.

Sources & evidence

ORD record
ord-006abab5afd54c0da949ef54c3f0af20
Source dataset
uspto-grants-1976_02
Patent number
US03940394

Reaction notes

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