反应详情

[4-Chloro-6-(p-chlorobenzylamino)-2-pyrimidinylthio]acetic acid ethyl ester (1.4 g) was heated for 5 minutes with 30 ml. of 30% sodium hydroxide solution on a hot plate. The reaction mixture was then cooled and acidified with concentrated hydrochloric acid solution. The resulting precipitate was removed by filtration, washed with water and recrystallized from ethanol to afford 1.0 g of product, mp. 211°-213°C., decomp.

1. temperatureThe reaction mixture was then cooled
2. customThe resulting precipitate was removed by filtration
3. washwashed with water
4. customrecrystallized from ethanol