反应详情

A stirred mixture of 1.1 g of (6-chloro-4-p-chlorobenzylamino-2pyrimidinylthio)acetic acid, ethyl ester 0.18 g of hydrazine hydrate (98%) and 0.3 g of sodium carbonate in 15 ml. of ethanol was heated under reflux for 3 hr. The reaction mixture was filtered and the filtrate diluted with water until a precipitate appeared. The solid was washed with aqueous (10%) sodium carbonate then recrystallized from ethanol to a mp. of 178-182°C.

1. temperatureunder reflux for 3 hr
2. filtrationThe reaction mixture was filtered
3. additionthe filtrate diluted with water until a precipitate
4. washThe solid was washed with aqueous (10%) sodium carbonate
5. customthen recrystallized from ethanol to a mp. of 178-182°C.