Diethyl Malonate → HCID 21557450, compound

HRID 1578963Notes

Reaction equation

HRID 1578963 reaction equation
Cl.[C:2]1([CH3:11])[CH:7]=[CH:6][C:5]([C:8]([NH2:10])=[NH:9])=[CH:4][CH:3]=1.[C:12](OCC)(=[O:19])[CH2:13][C:14](OCC)=[O:15]>>[C:2]1([CH3:11])[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:12](=[O:19])[CH2:13][C:14](=[O:15])[N:10]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7761Diethyl MalonateHCID 1227534-Methylbenzene-1-carboximidamide hydrochloride

Product 1

HCID 21557450HCID 21557450, compound

Procedure

Similarly, reacting p-toluamidine hydrochloride with diethyl malonate affords 2-(4-tolyl)-4,6-(1H,5H)-pyrimidinedione which is then reacted with phosphoryl chloride to produce 4,6-dichloro-2-(4-tolyl)-pyrimidine, m.p. 84°-85°C.

Sources & evidence

ORD record
ord-01da92ce86734d58bb1ed20f11fbdb16
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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