Diethyl Malonate → HCID 21557376, compound

HRID 1578965Notes

Reaction equation

HRID 1578965 reaction equation
Br.[Br:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][CH:4]=1.[C:12](OCC)(=[O:19])[CH2:13][C:14](OCC)=[O:15]>>[Br:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]2[NH:9][C:12](=[O:19])[CH2:13][C:14](=[O:15])[N:8]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 7761Diethyl MalonateHCID 22329612HCID 22329612, compound

Product 1

HCID 21557376HCID 21557376, compound

Procedure

In a similar manner, reacting p-bromobenzamidine hydrobromide with diethyl malonate produces 2-(4-bromophenyl)-4,6-(1H,5H)-pyrimidinedione, which is reacted with phosphoryl chloride to afford 2-(4-bromophenyl)-4,6-dichloropyrimidine.

Sources & evidence

ORD record
ord-946a74563b68431ca2e8e3f8ad6ebd9c
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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