N-(3-Aminopropyl)morpholine → HCID 21557433, compound

HRID 1578967Notes

Reaction equation

HRID 1578967 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12](Cl)[CH:11]=[C:10]([Cl:15])[N:9]=2)=[CH:4][CH:3]=1.[NH2:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([Cl:15])[CH:11]=[C:12]([NH:16][CH2:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:13]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 215573682-(4-Bromophenyl)-4,6-dichloropyrimidine

Product 1

HCID 21557433HCID 21557433, compound

Procedure

Similarly, 2-(4-bromophenyl)-4,6-dichloropyrimidine is reacted with N-(3-aminopropyl)-morpholine to afford 2-(4-bromophenyl)-4-chloro-6-[3-(morpholino)propylamino]pyrimidine which is then reacted with p-chlorothiophenol to produce 2-(4-bromophenyl)-4-(4-chlorophenylthio)-6-[3-(morpholinopropyl)amino]-pyrimidine.

Sources & evidence

ORD record
ord-e17753c58c9c41a2a790380bdc5bd4c7
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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