2-Methoxyethylamine → HCID 21557378, compound

HRID 1578970Notes

Reaction equation

HRID 1578970 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.[CH3:15][O:16][CH2:17][CH2:18][NH2:19]>O>[Cl:8][C:6]1[CH:7]=[C:2]([NH:19][CH2:18][CH2:17][O:16][CH3:15])[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 77338Fenclorim

Product 1

HCID 21557378HCID 21557378, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Seven grams of 4,6-dichloro-2-phenylpyrimidine is added in small portions to 30 ml. of β-methoxyethylamine with slight warming and stirring. The resulting mixture is heated on a steam bath for several minutes and then poured into 500 ml. of water. The product thus obtained (5.1 g.) is recrystallized from n-heptane to afford 4-chloro-6-(2-methoxyethylamino)-2-phenylpyrimidine, 48.5°-50°C.

Workup

  1. temperatureThe resulting mixture is heated on a steam bath for several minutes
  2. additionpoured into 500 ml
  3. customThe product thus obtained (5.1 g.)
  4. customis recrystallized from n-heptane

Sources & evidence

ORD record
ord-b677fff939dd422d8b153bbad164eb00
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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