2-Morpholinoethylamine → HCID 21557441, compound

HRID 1578976Notes

Reaction equation

HRID 1578976 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:3]=1.[NH2:16][CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[Cl:8][C:6]1[CH:7]=[C:2]([NH:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:5]=1

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 22353517HCID 22353517, compound

Product 1

HCID 21557441HCID 21557441, compound

Procedure

Employing the procedure of Example VII, 7.0 g. of 4,6-dichloro-2-(p-chlorophenyl)-pyrimidine and 30 ml. of N-(β-aminoethyl)-morpholine is reacted to produce 8.9 g. of product. Recrystallization from n-heptane affords 4-chloro-2-(4-chlorophenyl)-6-[2-(morpholino)ethylamino]-pyrimidine, m.p. 127°-129°C.

Workup

  1. customto produce 8.9 g
  2. customRecrystallization from n-heptane

Sources & evidence

ORD record
ord-485306adab08414caecbb7fa5f389973
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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