1-Methylpiperazine → 4-Chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine

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Reaction Steps

Two grams of 4,6-dichloro-2-phenylpyrimidine is added in small portions to 10 ml. of N-methylpiperazine with slight warming and stirring. An exothermic reaction takes place during the addition. The resulting mixture is heated on a steam bath for several minutes and then poured into 250 ml. of water. The product thus obtained is recrystallized from n-pentane to afford 4-chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine, m.p. 91°-92.5°C.

Provenance & Evidence