1-Methylpiperazine → 4-Chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine

HRID 1578978Notes

Reaction equation

HRID 1578978 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>O>[Cl:8][C:6]1[CH:7]=[C:2]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 77338Fenclorim

Product 1

HCID 215573834-Chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Two grams of 4,6-dichloro-2-phenylpyrimidine is added in small portions to 10 ml. of N-methylpiperazine with slight warming and stirring. An exothermic reaction takes place during the addition. The resulting mixture is heated on a steam bath for several minutes and then poured into 250 ml. of water. The product thus obtained is recrystallized from n-pentane to afford 4-chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine, m.p. 91°-92.5°C.

Workup

  1. customAn exothermic reaction
  2. additionduring the addition
  3. temperatureThe resulting mixture is heated on a steam bath for several minutes
  4. additionpoured into 250 ml
  5. customThe product thus obtained
  6. customis recrystallized from n-pentane

Sources & evidence

ORD record
ord-bc2a82f2c1864f519e69183877643678
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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