反应详情

Two grams of 4,6-dichloro-2-phenylpyrimidine is added in small portions to 10 ml. of N-methylpiperazine with slight warming and stirring. An exothermic reaction takes place during the addition. The resulting mixture is heated on a steam bath for several minutes and then poured into 250 ml. of water. The product thus obtained is recrystallized from n-pentane to afford 4-chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine, m.p. 91°-92.5°C.

1. customAn exothermic reaction
2. additionduring the addition
3. temperatureThe resulting mixture is heated on a steam bath for several minutes
4. additionpoured into 250 ml
5. customThe product thus obtained
6. customis recrystallized from n-pentane