N,N-Dimethylethylenediamine → HCID 21557415, compound

HRID 1578980Notes

Reaction equation

HRID 1578980 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[N:3]=1.[CH3:17][N:18]([CH3:22])[CH2:19][CH2:20][NH2:21]>O>[Cl:8][C:6]1[CH:7]=[C:2]([NH:21][CH2:20][CH2:19][N:18]([CH3:22])[CH3:17])[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 215574074,6-Dichloro-2-(3,4-dichlorophenyl)pyrimidine

Product 1

HCID 21557415HCID 21557415, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Seven grams of 4,6-dichloro-2-(3,4-dichlorophenyl)pyrimidine is added in small portions to 25 ml. of N,N-dimethylethylenediamine with slight warming and stirring. The resulting mixture is heated on a steam bath for several minutes then poured into 500 ml. of water. The product thus obtained is recrystallized from n-heptane to afford 4-chloro-2-(3,4-dichlorophenyl)-6-[2-(dimethylamino)ethylamino]-pyrimidine, m.p. 99.5°-102°C.

Workup

  1. temperatureThe resulting mixture is heated on a steam bath for several minutes
  2. additionthen poured into 500 ml
  3. customThe product thus obtained
  4. customis recrystallized from n-heptane

Sources & evidence

ORD record
ord-f220ff04220b4aa38eb88a6c56f901f2
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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