Ethanol → HCID 21557438, compound

Participants

Reaction Steps

a solution of 7.8 g. of 4,6-dichloro-2-(m-chlorophenyl)-pyrimidine and 6.0 g. of N-methylpiperazine in 35 ml. of absolute ethanol is refluxed for fifteen minutes. Pouring of the resulting solution into 700 ml. of water causes separation of a gummy material which solidifies on standing over a weekend. The crude product weighs 6.5 g. and recrystallization from n-heptane affords cotton-like crystals of 4-chloro-2-(3-chlorophenyl)-6-(4-methylpiperazin-1-yl)-pyrimidine, m.p. 93°-94°C.

Provenance & Evidence