Ethanol → HCID 21557438, compound

HRID 1578984Notes

Reaction equation

HRID 1578984 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)[N:3]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.C(O)C>O>[Cl:8][C:6]1[CH:7]=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]2)[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)[N:5]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 531671-MethylpiperazineHCID 226181414,6-Dichloro-2-(3-chlorophenyl)pyrimidine

Product 1

HCID 21557438HCID 21557438, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

a solution of 7.8 g. of 4,6-dichloro-2-(m-chlorophenyl)-pyrimidine and 6.0 g. of N-methylpiperazine in 35 ml. of absolute ethanol is refluxed for fifteen minutes. Pouring of the resulting solution into 700 ml. of water causes separation of a gummy material which solidifies on standing over a weekend. The crude product weighs 6.5 g. and recrystallization from n-heptane affords cotton-like crystals of 4-chloro-2-(3-chlorophenyl)-6-(4-methylpiperazin-1-yl)-pyrimidine, m.p. 93°-94°C.

Workup

  1. additionPouring of the resulting solution into 700 ml
  2. customseparation of a gummy material which
  3. waiton standing over a weekend
  4. customand recrystallization from n-heptane

Sources & evidence

ORD record
ord-8a463959da0c4ab6a2154e54e4bdac89
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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