1-Methylpiperazine → HCID 21557455, compound

Participants

Reaction Steps

Repeating the procedure of Example XX 7.2 g. of 4,6-dichloro-2-(p-tolyl)-pyrimidine and 6.0 g. of N-methylpiperazine are reacted in 40 ml. of absolute ethanol. The crude product (8.4 g.) is separated and twice recrystallized from n-heptane to afford 4-chloro-6-(4-methyl-1-piperazinyl)-2-(4-tolyl)-pyrimidine, m.p. 93°-95°C.

Provenance & Evidence