1-Methylpiperazine → HCID 21557455, compound

HRID 1578985Notes

Reaction equation

HRID 1578985 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[N:3]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>C(O)C>[Cl:8][C:6]1[CH:7]=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]2)[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 12703697HCID 12703697, compound

Product 1

HCID 21557455HCID 21557455, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Repeating the procedure of Example XX 7.2 g. of 4,6-dichloro-2-(p-tolyl)-pyrimidine and 6.0 g. of N-methylpiperazine are reacted in 40 ml. of absolute ethanol. The crude product (8.4 g.) is separated and twice recrystallized from n-heptane to afford 4-chloro-6-(4-methyl-1-piperazinyl)-2-(4-tolyl)-pyrimidine, m.p. 93°-95°C.

Workup

  1. customThe crude product (8.4 g.) is separated
  2. customtwice recrystallized from n-heptane

Sources & evidence

ORD record
ord-3b5fe0320d0b47d4949835831e341226
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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