HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 4-Chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 4,6-Dichloro-2-(4-methoxyphenyl)pyrimidine | HCID 12098357 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine | HCID 21557372 | — |
Reaction Steps
Employing the procedure of Example XX, 7.7 g. of 4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine is reacted with 6.0 g. of N-methylpiperazine in 45 ml. of absolute ethanol to afford 4-chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine, m.p. 88°-90°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03940395 |
| Source dataset | uspto-grants-1976_02 |
| ORD ID | ord-f74116e841f14d2da66e7e10fbe1d0c2 |
| Source note | uspto-grants-1976_02 |