1-Methylpiperazine → 4-Chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine

HRID 1578987Notes

Reaction equation

HRID 1578987 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[N:3]=1.[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>C(O)C>[Cl:8][C:6]1[CH:7]=[C:2]([N:21]2[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]2)[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 120983574,6-Dichloro-2-(4-methoxyphenyl)pyrimidine

Product 1

HCID 215573724-Chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Employing the procedure of Example XX, 7.7 g. of 4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine is reacted with 6.0 g. of N-methylpiperazine in 45 ml. of absolute ethanol to afford 4-chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine, m.p. 88°-90°C.

Sources & evidence

ORD record
ord-f74116e841f14d2da66e7e10fbe1d0c2
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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