2-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione → 2-[6-[4-(2-pyridinyl)-1-piperazinyl]-hexyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

HRID 1579013Notes

Reaction equation

HRID 1579013 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11](CCCCN2C(=O)C3C=CC=C4C=3C(=CC=C4)C2=O)[CH2:10][CH2:9]1.Br[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][N:40]1[C:49](=[O:50])[C:48]2[CH:51]=[CH:52][CH:53]=[C:46]3[C:47]=2[C:42](=[CH:43][CH:44]=[CH:45]3)[C:41]1=[O:54].BrCCCCN1C(=O)C2C=CC=C3C=2C(=CC=C3)C1=O>>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:9][CH2:10][N:11]([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][N:40]2[C:49](=[O:50])[C:48]3[CH:51]=[CH:52][CH:53]=[C:46]4[C:47]=3[C:42](=[CH:43][CH:44]=[CH:45]4)[C:41]2=[O:54])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 27823602-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dioneHCID 203645072-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dioneHCID 1317100602-[4-[4-(2-Pyridinyl)-1-piperazinyl]butyl]-1H-benz[de]-isoquinoline-1,3-(2H)-dione, hydrochloride

Product 1

HCID 1317100622-[6-[4-(2-pyridinyl)-1-piperazinyl]-hexyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

Procedure

Following the procedure of part (b) of example 46 but substituting 2-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dione for the 2-(4-bromobutyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione, one obtains 2-[6-[4-(2-pyridinyl)-1-piperazinyl]-hexyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride (1:2).

Sources & evidence

ORD record
ord-8aac111b24354791b43eb39c2a44dd1c
Source dataset
uspto-grants-1976_02
Patent number
US03940398

Reaction notes

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