2-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione → Hydrochloric Acid

HRID 1579017Notes

Reaction equation

HRID 1579017 reaction equation
[ClH:1].[C:2]1([N:8]2[CH2:13][CH2:12][N:11](CCCCN3C(=O)C4C=CC=C5C=4C(=CC=C5)C3=O)[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][N:40]1[C:49](=[O:50])[C:48]2[CH:51]=[CH:52][CH:53]=[C:46]3[C:47]=2[C:42](=[CH:43][CH:44]=[CH:45]3)[C:41]1=[O:54].BrCCCCN1C(=O)C2C=CC=C3C=2C(=CC=C3)C1=O>>[C:2]1([N:8]2[CH2:13][CH2:12][N:11]([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][N:40]3[C:49](=[O:50])[C:48]4[CH:51]=[CH:52][CH:53]=[C:46]5[C:47]=4[C:42](=[CH:43][CH:44]=[CH:45]5)[C:41]3=[O:54])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:1]

Participants

5

Reactant 3

HCID 27823602-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dioneHCID 203645072-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dioneHCID 1317100632-[4-(4-Phenyl-1-piperazinyl)butyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

Product 2

HCID 313Hydrochloric AcidHCID 64248032-[6-(4-Phenyl-piperazin-1-yl)-hexyl]-benzo[de]isoquinoline-1,3-dione

Procedure

Following the procedure of part (b) of example 34 but substituting 2-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dione for the 2-(4-bromobutyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione, one obtains 2-[6-(4-phenyl-1-piperazinyl)hexyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, )-dione, hydrochloride.

Sources & evidence

ORD record
ord-2ad014390e6246abb275e24a5bf6a71c
Source dataset
uspto-grants-1976_02
Patent number
US03940397

Reaction notes

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