Fuming sulfuric acid → HCID 178527626, compound

HRID 1579022Notes

Reaction equation

HRID 1579022 reaction equation
[Cl:1][C:2]1[C:10]2[NH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[N:7][C:6]=2[CH:5]=[C:4]([Cl:15])[C:3]=1[Cl:16].[OH:17][S:18](O)(=[O:20])=[O:19].O=S(=O)=O>O>[Cl:15][C:4]1[C:3]([Cl:16])=[C:2]([Cl:1])[C:10]2[N:9]=[C:8]([C:11]([F:14])([F:13])[F:12])[NH:7][C:6]=2[C:5]=1[S:18]([OH:20])(=[O:19])=[O:17]

Participants

4

Reactant 2

HCID 24681Fuming sulfuric acidHCID 178506267HCID 178506267, compound

Product 1

HCID 178527626HCID 178527626, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4,5,6-trichloro-2-trifluoromethylbenzimidazole (145 parts) was added gradually to stirred oleum (1260 parts) and the mixture then refluxed for 2 hours. After cooling, the mixture was poured into water (3000 parts), the temperature being allowed to rise to near boiling. The mixture was cooled to room temperature overnight and the crystalline product was filtered off, washed with water and dried to give 165.9 parts (92% yield) of 5,6,7-trichloro-2-trifluoromethylbenzimidazole-4-sulphonic acid.

Workup

  1. temperaturethe mixture then refluxed for 2 hours
  2. temperatureAfter cooling
  3. filtrationthe crystalline product was filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-6b92702c798b49e3a79be6f6beb328e5
Source dataset
uspto-grants-1976_02
Patent number
US03940416

Reaction notes

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