Thiosemicarbazide → 1-(1-Methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide

HRID 1579032Notes

Reaction equation

HRID 1579032 reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10](Cl)=[O:11].[NH2:13][NH:14][C:15]([NH2:17])=[S:16]>O1CCCC1>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]([NH:13][NH:14][C:15]([NH2:17])=[S:16])=[O:11]

Participants

4

Reactant 2

HCID 2723789ThiosemicarbazideHCID 109870491-Methyl-5-nitro-2-imidazolecarboxylic acid chloride

Product 1

HCID 214322521-(1-Methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 1-methyl-5-nitro-2-imidazolecarboxylic acid chloride (1.1 g.) in 25 ml. of dry tetrahydrofuran is added 0.55 g. powdered thiosemicarbazide and the mixture is stirred at room temperature for 24 hours. The reaction mixture is evaporated to dryness and water is added. The solution is made basic with sodium hydroxide and the solid is filtered, washed with water and dried affording 1-(1-methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide.

Workup

  1. customThe reaction mixture is evaporated to dryness and water
  2. additionis added
  3. filtrationthe solid is filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-154a9a3b63ac420c8e4453988c9ede40
Source dataset
uspto-grants-1976_02
Patent number
US03940411

Reaction notes

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