反应详情

A solution of 57 g. of methyl 4-(tetrahydropyran-2-yloxy)phenylacetate, in 2 l. of anhydrous tetrahydrofuran is added dropwise, over a 30 minute period to a stirred suspension of 20 g. of lithium aluminum hydride in 1 l. of anhydrous tetrahydrofuran, under nitrogen atmosphere. The mixture is refluxed for 90 minutes, cooled and cautiously treated with 20 ml. of ethyl acetate, to destroy the excess reagent. Solid sodium sulfate is added, the inorganic material filtered off and thoroughly washed with hot ethyl acetate. Upon evaporation of the combined organic filtrates there is obtained 4-(tetrahydropyran-2-yloxy)phenylethanol.

1. temperatureThe mixture is refluxed for 90 minutes
2. temperaturecooled
3. additioncautiously treated with 20 ml
4. customof ethyl acetate, to destroy the excess reagent
5. additionSolid sodium sulfate is added
6. filtrationthe inorganic material filtered off
7. washthoroughly washed with hot ethyl acetate
8. customUpon evaporation of the combined organic filtrates there