反应详情

A solution of 200 mg. of 4-[4(2,3-epoxypropoxy) phenyl]-1,2,3-thiadiazole in 10 ml. of anhydrous ethanol is saturated with ammonia and the reaction mixture is maintained at room temperature for 16 hours. The reaction mixture is then evaporated to dryness under vacuo, to yield the crude 4-[4(3-amino-2-hydroxypropoxy)phenyl]-1,2,3-thiadiazole, which can be further purified by thin layer chromatography.

1. customThe reaction mixture is then evaporated to dryness under vacuo