Tert-Butylamine → HCID 21557713, compound

HRID 1579058Notes

Reaction equation

HRID 1579058 reaction equation
[O:1]1[CH2:16][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][N:14]=[N:13][CH:12]=2)=[CH:7][CH:6]=1.[C:17]([NH2:21])([CH3:20])([CH3:19])[CH3:18]>C(O)(C)(C)C>[C:17]([NH:21][CH2:16][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][N:14]=[N:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:20])([CH3:19])[CH3:18]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 21557787HCID 21557787, compound

Product 1

HCID 21557713HCID 21557713, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

A mixture of 1.5 g. of 5-[4(2,3-epoxypropoxy) phenyl]-1,2,3-thiadiazole, 45 ml. of t-butylamine and 5 ml. of t-butanol is stirred at room temperature for 96 hours. It is then evaporated to dryness under reduced pressure and the residue crystallized from methanol-ether to afford the pure 5-[4(3-t-butylamino-2-hydroxypropoxy)phenyl]-1,2,3-thiadiazole, m.p. 133°-134° C; λmax 225-226, 314 nm (ε 760, 12300) ir 3390, 3210, 1655, 1615 cm-1.

Workup

  1. additionA mixture of 1.5 g
  2. customIt is then evaporated to dryness under reduced pressure
  3. customthe residue crystallized from methanol-ether

Sources & evidence

ORD record
ord-baec25188e2e486aa12adad0e98908e9
Source dataset
uspto-grants-1976_02
Patent number
US03940407

Reaction notes

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