反应详情

A mixture of 10 g. of isopropylamine, 2 g. of 4-[4(2,3-epoxypropoxy)phenyl]-1,2,3-thiadiazole and 10 ml. of isopropanol is refluxed under stirring for 6 hours. The isopropanol and unreacted isopropylamine are then removed by distillation under vacuo. Crystallization of the residue from methanol-ether produces the pure 4-[4(3-isopropylamino-2hydroxypropoxy)phenyl]-1,2,3-thiadiazole.

1. additionA mixture of 10 g
2. customThe isopropanol and unreacted isopropylamine are then removed by distillation under vacuo
3. customCrystallization of the residue from methanol-ether