Methylamine → HCID 21441263, compound

HRID 1579070Notes

Reaction equation

[C:1]([NH:4][C:5]1[CH:24]=[CH:23][CH:22]=[C:7]2[C:8]([N:10]([C:13]3([C:19](Cl)=[O:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[C:11](=[O:12])[C:6]=12)=[O:9])(=[O:3])[CH3:2].[CH3:25][NH2:26]>>[C:1]([NH:4][C:5]1[CH:24]=[CH:23][CH:22]=[C:7]2[C:8]([N:10]([C:13]3([C:19]([NH:26][CH3:25])=[O:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[C:11](=[O:12])[C:6]=12)=[O:9])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 6329Methylamine

HCID 21557901HCID 21557901, compound

Product 1

HCID 21441263HCID 21441263, compound

Procedure

Using the same procedure as described in Example 3 but replacing the ammonia with methylamine gives the title mono-methylamide, m.p. 168.5°-170°C. Similarly, reacting 1-(3-acetamidophthalimido)-cyclohexanecarbonyl chloride with methylamine yields 1-(3-acetamidophthalimido)-N-methylcyclohexanecarboxamide, m.p. 205°-207.5°C.

Sources & evidence

ORD record: ord-fe8c25bbde324e5b820ac2b59d207456
Source dataset: uspto-grants-1976_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03940419

Reaction notes

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