Hydrochloric Acid → HCID 21567166, compound

HRID 1579134Notes

Reaction equation

HRID 1579134 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:7][CH:6]=2.[ClH:15]>>[ClH:15].[CH3:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 2749733-Methyl-5-nitroisoquinoline

Product 1

HCID 21567166HCID 21567166, compound

Procedure

3-methyl-5-nitro-isoquinoline (6 g), prepared according to the method of Example 5 hereinabove, was dissolved in concentrated hydrochloric acid (30 ml). The excess acid was then removed by means of a rotary evaporator, and the residue was digested with boiling ethanol (100 ml). The mixture was cooled and filtered, and the residue was dried in vacuo for several hours, to yield 6.9 g of 3-methyl-5-nitro-isoquinoline hydrochloride melting over a temperature range from 178° to 183°C.

Workup

  1. customThe excess acid was then removed by means of a rotary evaporator
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customthe residue was dried in vacuo for several hours

Sources & evidence

ORD record
ord-9ee6f02f5fed4ac4bb2c56c65cb2fe69
Source dataset
uspto-grants-1976_01
Patent number
US03930837

Reaction notes

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