7-Phenylacetamidodeacetoxycephalosporanic acid → 7-Aminodeacetoxycephalosporanic acid

HRID 1579141Notes

Reaction equation

HRID 1579141 reaction equation
CC(O[CH2:5][C:6]1[CH2:28][S:27][C@@H:9]2[C@H:10]([NH:13]C(C(OC(C)=O)C3C=CC=CC=3)=O)[C:11](=[O:12])[N:8]2[C:7]=1[C:29]([OH:31])=[O:30])=O>O>[CH3:5][C:6]1[CH2:28][S:27][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:29]([OH:31])=[O:30]

Participants

3

Reactant 1

HCID 30822767-Phenylacetamidodeacetoxycephalosporanic acid

Product 1

HCID 334987-Aminodeacetoxycephalosporanic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

500 g of 7-phenylacetamido-desacetoxycephalosporanic acid were dissolved in 8.3 liters of water and split completely over the course of 4 hours at 38°C, by addition of 220 g of carrier-bound penicillinacylase (according to Example C), analogously to Example 2; the 7-amino-desacetoxycephalosporanic acid formed was precipitated and dried.

Workup

  1. customsplit completely over the course of 4 hours at 38°C, by addition of 220 g of carrier-bound penicillinacylase (according to Example C), analogously to Example 2

Sources & evidence

ORD record
ord-75bb6736811444d28f221d9e7ca2e204
Source dataset
uspto-grants-1976_01
Patent number
US03930949

Reaction notes

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