7-Phenylacetamidodeacetoxycephalosporanic acid → 7-Aminodeacetoxycephalosporanic acid

Participants

Reaction Steps

500 g of 7-phenylacetamido-desacetoxycephalosporanic acid were dissolved in 8.3 liters of water and split completely over the course of 4 hours at 38°C, by addition of 220 g of carrier-bound penicillinacylase (according to Example C), analogously to Example 2; the 7-amino-desacetoxycephalosporanic acid formed was precipitated and dried.

Provenance & Evidence