反应详情

A mixture of 1.99 g. of 4,7-dichloroquinazoline, 0.79 g. of 1,9-diaminononane, 2.5 g. of sodium carbonate and 25 ml. of isopropanol is stirred at room temperature for 2 hours. The reaction mixture is then diluted with 100 ml. of chloroform, filtered and concentrated in vacuo. The solid residue is crystallized from ethanol to obtain N,N'-bis(7-chloro-4-quinazolinyl)-1,9-nonanediamine, m.p. 190°-192°C. which is readily converted into dimethanesulfonate acid addition salt form which melts at 159°-162°C. on crystallization from ethanol/ether.

1. additionA mixture of 1.99 g
2. additionThe reaction mixture is then diluted with 100 ml
3. filtrationof chloroform, filtered
4. concentrationconcentrated in vacuo
5. customThe solid residue is crystallized from ethanol