反应详情

A stirred mixture of methyl 3-[2-(2,3-epoxypropoxy)benzoyl]-propionate (8.3g, 0.031 mole), methanol (85 ml), and isopropylamine (16.4 ml, 0.19 mole) was heated under reflux for 90 minutes. Evaporation of the solution under reduced pressure gave methyl 3-[2-(2-hydroxy-3-isopropylaminopropoxy)benzoyl]propionate (10.2 g, 100%) as a pale brown oil.

1. temperaturewas heated
2. temperatureunder reflux for 90 minutes
3. customEvaporation of the solution under reduced pressure