HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → Methyl 3-[2-(2-hydroxy-3-isopropylaminopropoxy)benzoyl]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Methyl 3-[2-(2,3-epoxypropoxy)benzoyl]propionate | HCID 13530373 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-[2-(2-hydroxy-3-isopropylaminopropoxy)benzoyl]propionate | HCID 20309568 | 101.7% |
Reaction Steps
A stirred mixture of methyl 3-[2-(2,3-epoxypropoxy)benzoyl]-propionate (8.3g, 0.031 mole), methanol (85 ml), and isopropylamine (16.4 ml, 0.19 mole) was heated under reflux for 90 minutes. Evaporation of the solution under reduced pressure gave methyl 3-[2-(2-hydroxy-3-isopropylaminopropoxy)benzoyl]propionate (10.2 g, 100%) as a pale brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931177 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-222c00f21df946358ad4dd72099e2d49 |
| Source note | uspto-grants-1976_01 |