Hydrochloric Acid → HCID 20309545, compound

HRID 1579300Notes

Reaction equation

HRID 1579300 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][CH:17]([OH:24])[CH2:18][NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[C:6]([CH:14]=1)[C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8].Cl.[C:26](=O)([O-])[O-].[Na+].[Na+]>CO.O>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][CH:17]([OH:24])[CH2:18][NH:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[C:6]([CH:14]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:26])=[O:12])=[O:8]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 20309496HCID 20309496, compound

Product 1

HCID 20309545HCID 20309545, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-[5-Amino-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]propionic acid was esterified with hydrogen chloride in methanol. Evaporation of the solution under reduced pressure gave a residue which was dissolved in the minimum of water and the solution was neutralised with sodium carbonate and extracted with dichloromethane. The combined extracts were washed with saturated brine, dried, and evaporated to give methyl 3-[5-amino-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]propionate.

Workup

  1. customEvaporation of the solution under reduced pressure
  2. customgave a residue which
  3. extractionextracted with dichloromethane
  4. washThe combined extracts were washed with saturated brine
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-3520a2a403344fc3962b583309a11051
Source dataset
uspto-grants-1976_01
Patent number
US03931177

Reaction notes

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