Hydrochloric Acid → HCID 21568344, compound

Participants

Reaction Steps

A mixture of 17.6 g (0.038 mole) of 4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]-1-(2-naphthyl)butan-1-one hydrochloride, 400 ml of concentrated HCl and 1500 ml of isopropyl alcohol is heated on a steam bath for 16 hours after which the solvent and excess acid are removed at reduced pressure. The remaining residue is recrystallized from isopropyl alcohol and ethyl acetate to give 4-[4-(diphenylmethylene)piperidino]-1-(2-naphthyl)butan-1-one hydrochloride.

Provenance & Evidence