Hydrochloric Acid → HCID 21568344, compound

HRID 1579332Notes

Reaction equation

HRID 1579332 reaction equation
[ClH:1].O[C:3]([CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][C:25]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=2)=[O:26])[CH2:18][CH2:17]1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>C(O)(C)C>[ClH:1].[C:10]1([C:3]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[C:16]2[CH2:17][CH2:18][N:19]([CH2:22][CH2:23][CH2:24][C:25]([C:27]3[CH:36]=[CH:35][C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:28]=3)=[O:26])[CH2:20][CH2:21]2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21568360HCID 21568360, compound

Product 1

HCID 21568344HCID 21568344, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 17.6 g (0.038 mole) of 4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]-1-(2-naphthyl)butan-1-one hydrochloride, 400 ml of concentrated HCl and 1500 ml of isopropyl alcohol is heated on a steam bath for 16 hours after which the solvent and excess acid are removed at reduced pressure. The remaining residue is recrystallized from isopropyl alcohol and ethyl acetate to give 4-[4-(diphenylmethylene)piperidino]-1-(2-naphthyl)butan-1-one hydrochloride.

Workup

  1. temperatureis heated on a steam bath for 16 hours after which the solvent and excess acid
  2. customare removed at reduced pressure
  3. customThe remaining residue is recrystallized from isopropyl alcohol and ethyl acetate

Sources & evidence

ORD record
ord-8dfbb2e2429d4ccbb42b7483ad2471f3
Source dataset
uspto-grants-1976_01
Patent number
US03931197

Reaction notes

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