反应详情

A solution of 0.06 mole sodium ethylate in ethyl alcohol is added dropwise while cooling to a suspension of 6.15 g (0.03 mole) of 2,4-dichloro-thieno[3,4-d]pyrimidine in 100 ml absolute ethyl alcohol. The speed of addition is regulated in such a way that the temperature of the reaction medium is maintained at between 0° and 5°C. When addition is completed, the solution is left to rise to room temperature and is then heated under reflux for 4 hours. It is then evaporated to dryness. The remaining solid is drained, washed with water and left to dry. AFter recrystallization from a 50/50 mixture of ethyl alcohol and water, 2.8 g (42% of theory) of 2,4-diethoxy-thieno[3,4-d]pyrimidine are obtained. M.P. 84°-86°C.

1. additionThe speed of addition
2. temperatureis maintained at between 0° and 5°C
3. additionWhen addition
4. waitthe solution is left
5. customto rise to room temperature
6. temperatureis then heated
7. temperatureunder reflux for 4 hours
8. customIt is then evaporated to dryness
9. washwashed with water
10. waitleft
11. customto dry
12. customAFter recrystallization
13. additionfrom a 50/50 mixture of ethyl alcohol and water, 2.8 g (42% of theory) of 2,4-diethoxy-thieno[3,4-d]pyrimidine
14. customare obtained