Propylamine → 2-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

Participants

Reaction Steps

A solution of 2.3 g (0.01 mole) of 2,4-diethoxy-thieno[3,4-d]pyrimidine and 3.6 g (0.06 mole) of n-propylamine in 50 ml absolute ethyl alcohol is heated under reflux for 10 hours. The solution is then evaporated to dryness. The solid is drained off, washed with water and dried. After recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine are obtained. M.P. 140°-142°C.

Provenance & Evidence