Propylamine → 2-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

HRID 1579427Notes

Reaction equation

HRID 1579427 reaction equation
[CH2:1]([O:3][C:4]1[N:5]=[C:6](OCC)[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2].[CH2:16]([NH2:19])[CH2:17][CH3:18]>C(O)C>[CH2:1]([O:3][C:4]1[N:5]=[C:6]([NH:19][CH2:16][CH2:17][CH3:18])[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 21568428HCID 21568428, compound

Product 1

HCID 215684642-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2.3 g (0.01 mole) of 2,4-diethoxy-thieno[3,4-d]pyrimidine and 3.6 g (0.06 mole) of n-propylamine in 50 ml absolute ethyl alcohol is heated under reflux for 10 hours. The solution is then evaporated to dryness. The solid is drained off, washed with water and dried. After recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine are obtained. M.P. 140°-142°C.

Workup

  1. temperatureunder reflux for 10 hours
  2. customThe solution is then evaporated to dryness
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine
  6. customare obtained

Sources & evidence

ORD record
ord-98122460a0e44fd8860c40a40c6481f6
Source dataset
uspto-grants-1976_01
Patent number
US03931204

Reaction notes

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