反应详情

2.5 G of 2-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid is dissolved in 80 ml of isopropyl alcohol. A solution of 2.1 g of aluminum isopropoxide in 25 ml of isopropyl alcohol is added dropwise to the solution with stirring, white crystals being immediately yielded. After refluxing the mixture for 1 hour, 3 ml of water is added, and then the whole mixture is further refluxed for 1 hour. After cooling, the crystals are filtered off, washed with isopropyl alcohol, and dried to give aluminum 2-(5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionate as white crystals melting at above 250°C.

1. customwhite crystals being immediately yielded
2. temperatureAfter refluxing the mixture for 1 hour
3. temperaturethe whole mixture is further refluxed for 1 hour
4. temperatureAfter cooling
5. filtrationthe crystals are filtered off
6. washwashed with isopropyl alcohol
7. customdried