反应详情

Dichloroacetylchloride (88 ml) in dichloromethane (200 ml) was added dropwise to a stirred solution of 2-aminobenzophenone (157.6g) in dichloromethane (400 ml) and triethylamine (116 ml) while keeping the temperature between 20°-30°C by cooling in ice. On completion of the addition the reaction was stirred at room temperature for 1.5 hours. The reaction mixture was washed with successive portions of distilled water-dilute hydrochloric acid and finally distilled water. After drying over anhydrous magnesium sulphate the solvent was removed under reduced pressure to leave a solid which on recrystallisation from absolute, ethanol gave 222 g of 2'-benzoyl-2,2-dichloroacetanilide, m.p. 112°-114°C.

1. custombetween 20°-30°C
2. temperatureby cooling in ice
3. additionOn completion of the addition the reaction
4. washThe reaction mixture was washed with successive portions of distilled water-dilute hydrochloric acid and finally distilled water
5. dry with materialAfter drying over anhydrous magnesium sulphate the solvent
6. customwas removed under reduced pressure
7. customto leave a solid which
8. customon recrystallisation from absolute, ethanol